Abstract: Roll-pitch seekers adopt the polar coordinate control form of rolling and pitching two axes. The outer frame is the rolling frame, the inner frame is the pitching frame, and the field of view can cover the entire front hemisphere. They have a simple structure, light weight, small volume, and low cost; therefore, they are very suitable for short-range infrared air defense missiles. This paper discusses the difference between the line-of-sight rates of roll–pitch seekers and pitch–yaw seekers and expounds the reason why roll–pitch seekers rotate around the x axis. The method of obtaining the line-of-sight rate of the roll–pitch seeker is given, the simplified form is deduced, and the conditions for using the simplified formula are analyzed. The simulation results show that the simplified formula has good approximation accuracy and certain engineering application prospects.