Abstract: Infrared thermometers are popular because of their safety, hygiene, and high efficiency. However, commercial infrared thermometers have large measurement errors and high cost, so their application is limited. Considering this, this paper first analyzes various factors that affect the measurement accuracy of an infrared thermometer and gives the calculation results of the specific influence degree. Then, using STM32F407 MCU as the control core, an MLX90615 infrared sensor, DS18B20 integrated temperature sensor, and HC-SR04 ultrasonic sensor to obtain information, a cheap and reliable portable infrared thermometer for hospitals and families is designed, and a method of temperature compensation is provided. Finally, the reliability of the system design was verified by testing. The test results show that the maximum comprehensive error is less than 0.15℃, which has definite practical value and reference value.