Abstract: Addressing issues such as the complex structure, high cost, and blurred radiation boundaries of calibration targets in traditional infrared camera calibration methods, this paper proposes an active circular hole grid thermal infrared binocular stereo calibration scheme. The calibration system consists of a thermal source system and a calibration board. The calibration board is made of asymmetric PVC hole board, with a simple structure and low manufacturing cost, and clear boundaries between high and low-temperature radiation areas. Moreover, this paper analyzes the influence of the spacing between circular holes, the number of circular holes, the diameter of circular holes, and the calibration distance on the calibration effect of the infrared camera, using the reprojection error as the evaluation criterion. The experimental results indicate that a calibration board with a circular hole spacing of around 60 mm, 36 circular holes, and a circular hole diameter of around 30 mm achieves the best calibration effect. The average reprojection error of the calibration image is 0.06 pixels. This calibration scheme effectively combines practical utility with cost-effectiveness, making it suitable for high-precision calibration of stereo vision systems utilizing both high- and low-resolution infrared cameras.