Abstract: With the development of high-resolution, high-frame-rate cooled infrared imagers, the phase-difference shift becomes more severe after converting the single-end differential signal as the frequency of the detector's analog output signal gradually increases. Therefore, to ensure the quality of infrared imaging, it is necessary to considered the issue of infrared image crosstalk. In self-developed 1280×1024@ 15 μm, we observed a phenomenon of note in the image testing of multiple movements such as the M-wave infrared imager. That is, when the right side of the infrared imaging image is a bright target and the left side target is relatively dark, the first four columns of the left image become brighter or darker due to the influence of the right side image. We define this phenomenon as image crosstalk, and find that it has a significant impact on the detection and recognition of uniform background targets. Through testing and simulation analyses, we concluded that the phase difference of the differential signals is one of the main causes of image crosstalk. We verified that setting the RC cutoff frequency to 0.707 times the clock rate of the main sampling clock of the detector when the analog differential signal enters the front end of the analog-to-digital converter can minimize the phase difference of differential signals and largely eliminate the problem of infrared image crosstalk.