Abstract: The refrigeration controller is an important component of an infrared remote sensing camera, and its temperature control accuracy directly affects the imaging quality of the camera. With increasing requirements for temperature control performance indicators and demand for refrigeration of camera components, the development of new multifunctional, high-performance, low-weight, and low-cost refrigeration controllers has become increasingly urgent. In response to these issues, a centralized multi-load infrared remote sensing camera refrigeration controller that adopts the method of circuit module reuse, temperature measurement, and control separation to achieve multi roads control was designed in this study. In terms of hardware, modular reuse and design miniaturization are carried out on the basis of traditional refrigeration controllers, achieving a centralized hardware product composed of a "single power supply, single master control, and multiple drivers." When a temperature measurement is proposed, the control separation method of "controller + temperature measurement box" is enacted and temperature data is collected nearby to ensure the temperature measurement accuracy and improve the temperature control accuracy. In terms of software, the design incorporates a complete software architecture, measurement and control temperature matching, independent design for multi load drives, and temperature data reliability, in conjunction with hardware solutions. Based on this design scheme, the experimental data of the "Drive and Road Three" refrigeration controller shows that the design meets the functional performance requirements of temperature matching, independent driving, and precise temperature control. At the same time, the cooling and temperature control accuracy of ± 8 mK fully meets the requirements of high-quality imaging, which makes this scheme feasible.